Replica (Replication Studies)
Replica is the name of the first time the most notorious studies on reduced-risk products using standard conditions that reflect the actual conditions of use.Cigarette smoking is an important risk factor for various aspects of health, related to cardiovascular, respiratory and lung cancer pathologies. Recently, the use of new generation smokeless products (NGP) appears to have significantly reduced the risks for smokers compared to smoking traditional cigarettes. In vitro preclinical biological tests are able to generate data for the evaluation of the risk reduction potential of NGPs, without resorting to investigations and tests on animals, using medium and high yield in vitro cellular screening technologies, based on exposure of cell cultures to aerosols/smoke through the use of automated platforms for multi-parametric screening, to monitor changes in biomarkers or proteins associated with biological activity that could indicate potential toxic effects.